9-cis retinoic acid

Understanding 9-cis Retinoic Acid: What It Is and How It Works

Retinoic Acid (RA) is a type of vitamin A that plays a vital role in cellular growth and differentiation, immune function, and vision. One of the forms of RA is 9-cis Retinoic Acid, which is known to be an essential signaling molecule involved in many biological processes. This blog will discuss the key points of 9-cis Retinoic Acid, including its chemical structure, functions, and potential benefits.

What is 9-cis Retinoic Acid?

9-cis Retinoic Acid is a type of retinoic acid that is structurally similar to other Vitamin A derivatives such as all-trans Retinoic Acid (ATRA) and 13-cis Retinoic Acid. The molecular formula of 9-cis Retinoic Acid is C20H28O2, and it is a stereo isomer of ATRA. It is known to be an essential regulator molecule involved in numerous physiological processes.

Functions of 9-cis Retinoic Acid

The primary function of 9-cis Retinoic Acid is to act as a ligand for certain nuclear receptors, such as retinoid X receptors (RXRs). These receptors are activated by binding to 9-cis Retinoic Acid, which triggers a cascade of signaling pathways. This, in turn, regulates gene expression within the cell. These pathways are involved in several critical functions, including:

  • The regulation of cellular differentiation
  • Modulation of cell growth and proliferation
  • Immune function
  • Vision

Several different biological pathways are regulated by 9-cis Retinoic Acid, making it one of the most important forms of Vitamin A. Its role in the body is to help ensure that these critical processes occur correctly.

Potential Benefits of 9-cis Retinoic Acid

Research into the benefits of 9-cis Retinoic Acid is still ongoing, but several potential benefits have been identified, including:

  • Improved immune function
  • Potential anti-inflammatory properties
  • Promoting healthy skin
  • Preventing some types of cancer

One study, published in the journal Molecular Medicine, found that 9-cis Retinoic Acid could help prevent the growth of breast cancer cells in the laboratory. This is because the molecule can regulate the expression of certain genes that are involved in the progression of the disease. Additionally, other studies have suggested that 9-cis Retinoic Acid may be useful in treating inflammatory disorders, such as Crohn’s disease, by reducing inflammation in the gut.


9-cis Retinoic Acid is an essential signaling molecule that plays a crucial role in many biological processes. Its ability to regulate gene expression makes it a vital component of numerous pathways, including those related to cell growth, immune function, and vision. Although research into the potential benefits of 9-cis Retinoic Acid is ongoing, it has shown promise in several areas, including preventing some types of cancer and reducing inflammation. As research progresses, we may continue to discover new ways in which this molecule can benefit our health and wellbeing.