Kinases:
Aurora kinases are a family of Ser/Thr protein kinases involved in cell division and numerous other cellular processes. Aurora kinases have become a hot area of research for their role in cancer pathogenesis and as viable targets for cancer therapeutics. Among the three Aurora kinases, Aurora A and Aurora B kinases are the most widely studied. In recent years, the discovery of small molecule inhibitors targeting Aurora A-B kinases has opened new avenues for cancer treatment.
Aurora A-B kinase inhibitors have been developed using rational drug design strategies, computer-aided drug discovery, and high-throughput screening of chemical libraries. Aurora libraries are a collection of small molecules that inhibit the activity of Aurora kinases in cells. These libraries consist of structurally diverse compounds with varying potency, specificity, and mechanism of action.
The development of Aurora kinase inhibitors has revolutionized cancer treatment by providing a precision medicine approach that targets specific proteins implicated in cancer cell survival, proliferation, and metastasis. Aurora inhibitors offer a benefit over traditional chemotherapy approaches by sparing normal dividing cells and reducing the side effects associated with cancer treatments.
Currently, several Aurora kinase inhibitors have received FDA approval for the treatment of different types of cancers. Examples include Alisertib (MLN8237) and Ispinesib (SB-715992) that specifically target Aurora A kinase, and GSK1070916 targeting Aurora B kinase. These small molecules have shown remarkable efficacy in preclinical and clinical studies as single agents, in combination with other drugs, or as a part of targeted therapy.
In conclusion, Aurora A-B kinase-targeted therapy using Aurora libraries is a promising cancer therapeutic strategy that provides disease-specific treatment with minimal side effects. The development of more Aurora kinase inhibitors with improved efficacy and safety is underway, paving the way for a new era of personalized and targeted cancer treatment. With the continued advancement of research on Aurora A-B kinase inhibitors, we hope to see improved cancer outcomes in patients.